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Expert Systems Joins Eilean’s PTPN2 Inhibitor Program

Eilean to leverage Expert Systems’ AI platform to help advance a new pipeline of best-in-class immuno-oncological therapy solutions.

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By: Charlie Sternberg

Associate Editor, Contract Pharma

Expert Systems, an expert in AI-enabled drug discovery, has expanded its collaboration with Eilean Therapeutics as it joins its new PTPN2 inhibitor program, which Eilean recently acquired from Ness Therapeutics Inc in an all-equity transaction.
 
Protein tyrosine phosphatase non-receptor type 2 (PTPN2), also known as T cell protein tyrosine phosphatase (TC-PTP), is ubiquitously expressed, primarily in hematopoietic and placental cells. As a critical negative regulator of the JAK-STAT pathway, PTPN2 functions to directly regulate signaling through cytokine receptors, including IFNγ. Thus, enhancing IFNγ sensing and signaling through the inhibition of PTPN2 is a potential therapeutic strategy to improve the efficacy of cancer immunotherapy regimens.
 
“Eilean’s lead PTPN2 inhibitor molecules demonstrate exceptional efficacy, selectivity, oral bioavailability and a good safety profile,” commended Bill Farley, CBO at Expert Systems. “We’re proud to be Eilean’s partner & leverage our cutting-edge AI platform to help advance a new pipeline of best-in-class immuno-oncological therapy solutions with an improved safety and tolerability profile.”

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